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Literature summary for 2.7.7.84 extracted from
- The role of mouse 2',5'-oligoadenylate synthetase 1 paralogs (2016), Infect. Genet. Evol., 45, 393-401 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene OAS1, cloning of paralogues OAS1a-OAS1h, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of EGFP-tagged isozyme paralogue in HEK-293T cell | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 ATP | Mus musculus | - |
pppA2'p5'A2'p5'A + 2 diphosphate | - |
? | |
| 3 ATP | Mus musculus C57BL/6J (B6) | - |
pppA2'p5'A2'p5'A + 2 diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P11928 | - |
- |
| Mus musculus | Q14AZ4 | - |
- |
| Mus musculus | Q60856 | OAS1b is derived from feral mouse strain, MSM | - |
| Mus musculus | Q8C2W3 | - |
- |
| Mus musculus | Q8K469 | - |
- |
| Mus musculus | Q8VI95 | - |
- |
| Mus musculus | Q8VI97 | - |
- |
| Mus musculus | Q924S2 | - |
- |
| Mus musculus C57BL/6J (B6) | P11928 | - |
- |
| Mus musculus C57BL/6J (B6) | Q14AZ4 | - |
- |
| Mus musculus C57BL/6J (B6) | Q60856 | OAS1b is derived from feral mouse strain, MSM | - |
| Mus musculus C57BL/6J (B6) | Q8C2W3 | - |
- |
| Mus musculus C57BL/6J (B6) | Q8K469 | - |
- |
| Mus musculus C57BL/6J (B6) | Q8VI95 | - |
- |
| Mus musculus C57BL/6J (B6) | Q8VI97 | - |
- |
| Mus musculus C57BL/6J (B6) | Q924S2 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | in the brain, only Oas1a, Oas1b, and Oas1g are expressed in the mice stimulated with poly I:C | Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| ovary | - |
Mus musculus | - |
| skin | - |
Mus musculus | - |
| spleen | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 ATP | - |
Mus musculus | pppA2'p5'A2'p5'A + 2 diphosphate | - |
? | |
| 3 ATP | - |
Mus musculus C57BL/6J (B6) | pppA2'p5'A2'p5'A + 2 diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2',5'-oligoadenylate synthetase 1 | - |
Mus musculus |
| OAS1 | - |
Mus musculus |
| OAS1A | - |
Mus musculus |
| OAS1b | - |
Mus musculus |
| OAS1c | - |
Mus musculus |
| OAS1d | - |
Mus musculus |
| OAS1e | - |
Mus musculus |
| OAS1f | - |
Mus musculus |
| OAS1g | - |
Mus musculus |
| OAS1h | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | the expression of OAS1c is relatively independent of the poly I:C stimulation | additional information |
| Mus musculus | expression of Oas1a, Oas1b, and Oas1g is much increased by the stimulation of poly I:C in all tissues, suggesting that these paralogues are expressed mainly in a virus- or interferon-stimulated manner, expression of other paralogues is restricted to the specific tissues and relatively independent of the poly I:C stimulation | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | in mice, the OAS gene family locates on chromosome 5 and consists of eight genes of Oas1 (Oas1a through Oas1h), Oas2, Oas3, and two OasL genes (OasL1 and OasL2). Oas1a and Oas1g are only active to convert ATP into di- and tri-2,5A, whereas Oas1b, Oas1c, Oas1d, Oas1e, Oas1f, Oas1h and MSM-derived Oas1b are inactive | Mus musculus |
| metabolism | only Oas1a and Oas1g show enzymatic activity. Although MSM-derived Oas1b shows antiviral activity in BHK-21 cells to both viruses, the two neurotropic flaviviruses, West Nile virus and tick-borne encephalitis virus, but all B6-derived OAS paralogues do not show antiviral activity. Paralogues Oas1a and Oas1g play a role in potentiating viral RNA-induced interferon response in the cell, whereas the paralogue Oas1b works as a specific anti-flavivirus factor unless it is mutated. The role of other paralogues (OAS1c, d, e, f, and h) is unknown to date | Mus musculus |
| metabolism | only Oas1a and Oas1g show enzymatic activity. Although MSM-derived Oas1b shows antiviral activity to both viruses, the two neurotropic flaviviruses, West Nile virus and tick-borne encephalitis virus, but all B6-derived OAS paralogues do not show antiviral activity. Paralogues Oas1a and Oas1g play a role in potentiating viral RNA-induced interferon response in the cell, whereas the paralogue Oas1b works as a specific anti-flavivirus factor unless it is mutated. The role of other paralogues (OAS1c, d, e, f, and h) is unknown to date | Mus musculus |
| physiological function | mouse Oas1b provides resistance to flavivirus infection, and Oas1b is enzymatically inactive and independent of RNase L | Mus musculus |
| physiological function | Oas1a, Oas1b, and Oas1g genes play a general role in various tissues in the stimulation of virus or interferon, whereas other paralogues work as somewhat specific factors in the respective tissues | Mus musculus |
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Release 2023.1 (January 2023)
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